Copper(II)-Mediated, Site-Selective C(sp2)–H Sulfonamidation of 1-Naphthylamines

Published in: J. Org. Chem

DOI: 10.1021/acs.joc.3c01852

Authors: Arun Kumar Hajra(TCGLS Member), Prasanjit Ghosh*, Priyanka Paul(TCGLS Member), Mrinalkanti Kundu*(TCGLS Member), and Sajal Das*

Abstract: An operationally simple and efficient protocol for copper(II)-mediated, picolinamido-directed C8–H sulfonamidation of 1-naphthylamine derivatives with various sulfonamides has been developed. Remarkably, this cross-dehydrogenative C–H/H–N coupling reaction exhibits a broad substrate scope with excellent functional group tolerance, is scalable, and enables an expeditious route to a library of unsymmetrical N-arylated sulfonamides in good to excellent yields with exclusive site selectivity.