8-Aminoimidazo[1,2-a]pyridine (AIP) directed Pd(II) catalysis: site-selective ortho-C(sp2)–H arylation in aqueous medium

Biswajit Mondal (TCGLS Member); Prasanjit Ghosh; Mrinalkanti Kundu; (TCGLS Member); Sajal Das

DOI : https://doi.org/10.1039/D0OB02510K

Abstract: We demonstrate herein the first example of a palladium(II) catalyzed regioselective ortho-C(sp2)–H arylation in aqueous medium (a sustainable solvent) utilizing 8-AIP (8-aminoimidazo[1,2-a]pyridine) as a promising and removable bidentate directing group/auxilliary. This newly developed protocol features a broad substrate scope with excellent functional group tolerance and enables an expeditious route to a library of unsymmetrical amides in good to excellent yields with exclusive site-selectivity