In Vivo Pharmacology
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In Vivo Pharmacology

TCG Lifesciences In Vivo service provides validated platforms for in-depth studies in the therapeutic areas of Pain, Inflammation and CNS with special focus on Neuropathic pain. Our talented research team led by Ph.D. scientists in Pharmacology and Veterinary Sciences provide complete support from study designing to final data analysis and reporting. The TCGLS biology team offers the flexibility of using our platforms or developing customized models efficiently to enable your preclinical discovery program. Our team of In Vivo scientists work in concert with our In Vitro and Bioanalytical teams to support more complex study designs like PK/PD correlation including biomarker analysis and maximize the value of obtained research data.

The animal house of TCG Lifesciences is equipped with a state of art holding facility as well as in house breeding capabilities for reliable supply of rodent strains commonly required to support discovery research. The facility strictly adheres to the ethical guidelines of the Government of India and is under supervision of a fully compliant Institutional Animal Ethics Committee (IAEC). Our facility is licensed by Government of India to import special rodent strains as may be required by study protocols.

Models currently available for employment in projects:


Pain

Neuropathic pain

  • Spinal Nerve Ligation (Chung’s model)
  • Spared Nerve Injury (Woolf’s model)
  • Chronic Constriction Injury (Bennett’s model)
  • Partial Sciatic Nerve Ligation (Selzter’s model)
  • Tibial Nerve Transection
  • Diabetic neuropathy

Inflammatory pain

  • Ultraviolet radiation induced Hyperalgesia
  • Freund's Adjuvant induced Hyperalgesia
  • Formalin induced Pain
  • Carrageenan induced Hyperalgesia
  • MIA/MMT-induced OA
  • Post Operative Pain (POP, Brennan’s Model)

Mechanical & Thermal Nociception

  • Rat Pinch Model
  • Tail Flick

Visceral pain

  • Acetic Acid induced Writhing

Inflammation

Acute inflammation

  • Carrageenan induced Paw Edema
  • Carrageenan-Air Pouch Inflammation
  • LPS induced Endotoxemia
  • LPS induced Lung Inflammation
  • Delayed Type Hypersensitivity

Chronic inflammation

  • Collagen induced Arthritis
  • DSS induced Colitis
  • BDL induced Liver Fibrosis
  • BDL induced Liver Cirrhosis

CNS

  • Contextual Fear Conditioning (CFC) test for Learning and Memory
  • Novel Object Recognition Test (NORT) for Learning and Memory
  • Novel Environment Recognition Test (NERT) for Learning and Memory
  • Forced Swim Test for Depression
  • Stress induced Hyperthermia for Anxiety
  • MPTP induced Parkinsonism for Neuro-degeneration
  • Synaptic Plasticity changes (Field Potential recording in Hippocampal slices)

Other Models

  • Streptozotocin induced T1 Diabetes
  • Locomotor Activity test
  • Motor Liability test in rat with Rotarod
List of critical equipment>>
Contact Us
Preclinical Discovery:
brlresearch@chembiotek.com

R&D Centers in India:
Kolkata
+91 33 23673151/52
Business Development: India
contact.in@tcgls.com
USA
contact.us@tcgls.com
Europe
contact.eu@tcgls.com
Japan

contact.jp@tcgls.com

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