Molecular Pharmacology
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Molecular Pharmacology

Molecular Biology and Gene Expression

Develop innovative assays and screening methods to evaluate the effects of chemical compounds on cellular, molecular and biochemical processes. The screens, further help to unravel cell functions/biological process and could become potential therapeutic candidates in drug development pipeline.

Expertise includes:

  • Cell line development services in line with assay requirements (validation and optimization included)
  • Diverse range of In Vitro assays (primary, secondary and tertiary) optimized and validated in multiple therapeutic areas.
  • Adopting screening assays from bench scale assays to automation and scale up in 96 and 384 plate formats.
  • Tech transfer technology effectively implemented
  • Statistical analysis of the data sacrosanctly satisfy pre-defined acceptance criteria
  • Primary cell-based specialized assays across therapeutic areas.

Therapeutic Areas

  • Cardiovascular & Metabolic Disorders
  • Inflammation and pain
  • CNS
  • Oncology
  • Anti-infectives (anti-bacterial & anti-fungal)

Targets

  • GPCR
  • Ion channel
  • Enzyme
  • NHR
  • Transporter

List of critical equipment>>


Platforms & Assay Technologies

  • Alphascreen
  • Beta arrestin
  • cAMP
  • ELISA (Classical/HTRF)
  • Enzyme assays: Fluorescence & radio-isotope labeled
  • Fluorescence Polarization
  • GTPgamma binding
  • HTRF
  • Intracellular calcium mobilization
  • LCMS based assay
  • Mechanistic Characterization: Competitive, non-competitive & Allosteric
  • Radioligand binding (SPA & filtration)
  • Thallium flux
  • TR-FRET
  • Ultraluminescence
  • Voltage sensitive dye assays
  • Voltage sensor probe-based FRET assay
List of critical equipment>>

List of assays>>

Contact Us
Preclinical Discovery:
brlresearch@chembiotek.com

R&D Centers in India:
Kolkata
+91 33 23673151/52
Business Development: India
contact.in@tcgls.com
USA
contact.us@tcgls.com
Europe
contact.eu@tcgls.com
Japan

contact.jp@tcgls.com