DMPK
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Drug Metabolism & Pharmacokinetics (DMPK)

TCGLS has more than 10 years of experience in providing DMPK and bioanalytical services to global pharmaceutical, biotech, animal health companies supporting their preclinical drug discovery programs. Our DMPK facility is well equipped with high-end instrumentation, liquid handling & LC-MS systems as well as In-house supply of quality rodents for in-life system.

Our team of highly skilled and dedicated scientists has extensive experience in broad spectrum of DMPK studies add value to our customers’ discovery efforts by providing reliable data in an economic and efficient manner. We offer flexible solutions to develop customized assays as needed during the course of discovery programs to rapidly adapt to the needs of our customers’ programs.

Services:

In Vitro ADME

  • Physicochemical screening – Kinetic & thermodynamic solubility, chemical stability, LogD, LogP
  • Biorelevant solubility – FaSSIF, FeSSIF, SGF
  • Cell permeability – PAMPA, Caco-2, MDCK-II, MDCK-MDR1
  • Transporter assay – PGP, BCRP, MRP-2
  • Metabolic stability – S9, microsomes & hepatocytes
  • Microsomal & hepatocellular binding
  • Drug-drug interaction – CYP inhibition & induction
  • Time dependent drug-drug interaction (TDI)
  • Plasma protein binding
  • Plasma stability
  • Brain tissue binding
  • Blood to plasma ratio
  • Metabolite identification – Microsomes & hepatocytes
  • CYP450 reaction phenotyping

In Vivo Pharmacokinetics (Rats/Mice)

  • Discovery formulation development
  • Bioavailability study (PO, IP, IV, IM, SC, ID, IT etc.)
  • Preclinical bioequivalence study
  • Single/multiple dose PK with bioanalysis
  • Cassette (5-in-one) PK with bioanalysis
  • Dry blood spot (DBS) sampling & analysis
  • Tissue/ CSF distribution study
  • CNS penetration study
  • Drug administration through IV infusion/osmotic pump
  • Non-compartmental pharmacokinetic analysis, WinNonLin
  • Metabolite identification/quantitation

In Vivo Toxicokinetics

  • Formulation optimization with exposure evaluation
  • LC-MS/MS bioanalysis of TK samples

Discovery Bioanalysis

  • Non-GLP LC-MS/MS bioanalytical support
  • Bioanalysis of biofluids – Plasma, blood, CSF, urine, bile, synovialfluid etc.
  • Bioanalysis of tissues – Brain, liver, spleen, lung, muscle, paw, fat tissue etc.
  • Biomarker analysis
  • Peptide analysis
  • Chiral analysis


List of critical equipment>>
Contact Us
Preclinical Discovery:
brlresearch@chembiotek.com

R&D Centers in India:
Kolkata
+91 33 23673151/52
Business Development: India
contact.in@tcgls.com
USA
contact.us@tcgls.com
Europe
contact.eu@tcgls.com
Japan

contact.jp@tcgls.com